Shkenc\u00ebtar\u00ebt tregojn\u00eb se nj\u00eb \u00e7rregullim n\u00eb nivelin e neurotransmetuesve mund t\u00eb luaj\u00eb nj\u00eb rol t\u00eb r\u00ebnd\u00ebsish\u00ebm n\u00eb shfaqjen e tinitusit – zumbim i vazhduesh\u00ebm n\u00eb vesh\u00eb, i cili hap der\u00ebn p\u00ebr terapi t\u00eb reja.<\/p>\n
Tinnitusi , nj\u00eb gjendje e p\u00ebrshkruar nga miliona njer\u00ebz n\u00eb mbar\u00eb bot\u00ebn si gum\u00ebzhitje, fishk\u00ebllim\u00eb ose zum\u00eb e vazhdueshme n\u00eb vesh\u00eb, mund t\u00eb jet\u00eb m\u00eb e lidhur me kimin\u00eb e trurit nga sa mendohej m\u00eb par\u00eb.<\/p>\n
Hulumtimet e reja tregojn\u00eb rolin e r\u00ebnd\u00ebsish\u00ebm t\u00eb nj\u00eb neurotransmetuesi ky\u00e7 n\u00eb zhvillimin e k\u00ebtij \u00e7rregullimi, gj\u00eb q\u00eb mund t\u00eb \u00e7oj\u00eb n\u00eb trajtime m\u00eb t\u00eb sakta dhe efektive n\u00eb t\u00eb ardhmen.<\/p>\n
Edhe pse tinitusi shpesh shoq\u00ebrohet me humbjen e d\u00ebgjimit ose ekspozimin ndaj zhurmave t\u00eb forta, shkenc\u00ebtar\u00ebt dyshojn\u00eb gjithnj\u00eb e m\u00eb shum\u00eb se rr\u00ebnj\u00ebt e tij q\u00ebndrojn\u00eb m\u00eb thell\u00eb – n\u00eb m\u00ebnyr\u00ebn se si truri p\u00ebrpunon sinjalet zanore.Neurotransmetuesi serotonin, i njohur m\u00eb s\u00eb miri p\u00ebr rolin e tij n\u00eb rregullimin e humorit, mund t\u00eb ndikoj\u00eb gjithashtu n\u00eb ashp\u00ebrsin\u00eb e tinitusit, sipas nj\u00eb studimi t\u00eb ri.<\/p>\n
Sipas nj\u00eb studimi te minjt\u00eb nga shkenc\u00ebtar\u00eb n\u00eb SHBA dhe Kin\u00eb, rritja e sinjalizimit t\u00eb serotonin\u00ebs n\u00eb nj\u00eb qark specifik t\u00eb trurit rriti sjelljet e shoq\u00ebruara me nj\u00eb \u00e7rregullim neurologjik.<\/p>\n
Meqen\u00ebse serotonina shpesh synon t\u00eb leht\u00ebsoj\u00eb simptomat e depresionit dhe ankthit, ky zbulim mund t\u00eb ndihmoj\u00eb n\u00eb zhvillimin e trajtimeve q\u00eb leht\u00ebsojn\u00eb k\u00ebto gjendje pa p\u00ebrkeq\u00ebsuar tinitusin.<\/p>\n
“Dyshonim se serotonina kishte t\u00eb b\u00ebnte me tinitusin, por nuk e kuptuam v\u00ebrtet se si. Tani, duke p\u00ebrdorur sjelljen e minjve, gjet\u00ebm nj\u00eb qark specifik t\u00eb trurit q\u00eb p\u00ebrfshin serotonin\u00ebn dhe shkon direkt n\u00eb sistemin d\u00ebgjimor – dhe zbuluam se mund t\u00eb shkaktoj\u00eb efekte t\u00eb ngjashme me tinitusin”, thot\u00eb neuroshkenc\u00ebtari Zheng-Quan Tang i Universitetit Anhui n\u00eb Kin\u00eb.<\/p>\n
Shum\u00eb pacient\u00eb q\u00eb vuajn\u00eb nga tinitus raportojn\u00eb gjithashtu ankth dhe depresion.<\/p>\n
Tinitusi zakonisht p\u00ebrkufizohet si nj\u00eb tingull “fantazm\u00eb” q\u00eb d\u00ebgjohet vet\u00ebm nga pacienti, shpesh nj\u00eb tingull me frekuenc\u00eb t\u00eb lart\u00eb, fishk\u00ebllim\u00eb, gum\u00ebzhitje ose pulsim. Disa nga mekanizmat themelor\u00eb jan\u00eb t\u00eb njohur, si\u00e7 jan\u00eb humbja e d\u00ebgjimit ose grumbullimi i cerumenit, por n\u00eb shum\u00eb raste duket t\u00eb jet\u00eb nj\u00eb problem neurologjik, i gjeneruar jo n\u00eb vesh\u00eb, por n\u00eb sistemin funksional t\u00eb trurit.<\/p>\n
\u00cbsht\u00eb e v\u00ebshtir\u00eb t\u00eb p\u00ebrshkruash vuajtjet e pam\u00ebshirshme t\u00eb nj\u00eb sistemi d\u00ebgjimor q\u00eb thjesht nuk hesht, por shum\u00eb pacient\u00eb raportojn\u00eb gjithashtu depresion, ankth dhe ide vet\u00ebvras\u00ebse. Trajtimi p\u00ebr k\u00ebto \u00e7rregullime t\u00eb humorit shpesh p\u00ebrfshin nj\u00eb klas\u00eb ila\u00e7esh t\u00eb quajtura frenues selektiv\u00eb t\u00eb rimarrjes s\u00eb serotonin\u00ebs (SSRI), t\u00eb cil\u00ebt bllokojn\u00eb rithithjen e serotonin\u00ebs n\u00eb neurone, duke rritur sinjalizimin e serotonin\u00ebs.<\/p>\n
Disa studime gjat\u00eb dekadave t\u00eb fundit kan\u00eb sugjeruar nj\u00eb lidhje midis serotonin\u00ebs dhe tinitusit, por kan\u00eb munguar prova t\u00eb drejtp\u00ebrdrejta t\u00eb lidhjes dhe mekanizmit. P\u00ebr t\u00eb hetuar k\u00ebt\u00eb mekaniz\u00ebm, studiuesit hartuan nj\u00eb eksperiment mbi minj.<\/p>\n
S\u00eb pari, ata hartuan rrug\u00ebn nga rajoni q\u00eb prodhon serotonin n\u00eb trungun e trurit deri te rajoni d\u00ebgjimor. Kjo rrug\u00eb ndihmon n\u00eb rregullimin e m\u00ebnyr\u00ebs se si p\u00ebrpunohen sinjalet zanore n\u00eb tru. Pastaj ata modifikuan gjenetikisht minjt\u00eb n\u00eb m\u00ebnyr\u00eb q\u00eb ata t\u00eb mund t\u00eb p\u00ebrdorin drit\u00ebn ose ila\u00e7et p\u00ebr t\u00eb aktivizuar neuronet q\u00eb \u00e7lirojn\u00eb serotonin\u00ebn.<\/p>\n
Minjt\u00eb me qarkun e serotonin\u00ebs t\u00eb ndezur dhe nj\u00eb grup kontrolli minjsh u testuan m\u00eb pas duke p\u00ebrdorur disa modele p\u00ebr t\u00eb par\u00eb n\u00ebse ata silleshin n\u00eb nj\u00eb m\u00ebnyr\u00eb q\u00eb sugjeronte se po p\u00ebrjetonin tinguj subjektiv\u00eb.<\/p>\n
“Kur stimulohen k\u00ebto neurone serotonergjike, mund t\u00eb shohim se kjo stimulon aktivitetin n\u00eb rajonin d\u00ebgjimor t\u00eb trurit. Gjithashtu pam\u00eb se kafsh\u00ebt sillen sikur t\u00eb vuanin nga tinitusi. Me fjal\u00eb t\u00eb tjera, kjo prodhon simptoma q\u00eb do t\u00eb prisnim t’i p\u00ebrjetonim si tinitus tek njer\u00ebzit”, thot\u00eb neurologu Lawrence Trussell i Universitetit t\u00eb Sh\u00ebndetit dhe Shkenc\u00ebs n\u00eb Oregonin.<\/p>\n
Kur ata p\u00ebrdor\u00ebn mjete frenuese p\u00ebr ta mbyllur plot\u00ebsisht k\u00ebt\u00eb qark serotonergjik-d\u00ebgjues, sjellja e ngjashme me tinitusin tek minjt\u00eb u ul. Dhe s\u00eb fundmi, kur ata p\u00ebrdor\u00ebn nj\u00eb zhurm\u00eb t\u00eb lart\u00eb p\u00ebr t\u00eb shkaktuar tinitus, minjt\u00eb u soll\u00ebn n\u00eb t\u00eb nj\u00ebjt\u00ebn m\u00ebnyr\u00eb si kur aktiviteti i serotonin\u00ebs u rrit.<\/p>\n
Rezultatet sugjerojn\u00eb se lidhja midis serotonin\u00ebs dhe tinitusit \u00ebsht\u00eb reale dhe se ky qark i trurit mund t\u00eb luaj\u00eb nj\u00eb rol t\u00eb drejtp\u00ebrdrejt\u00eb n\u00eb krijimin e tingujve fantazm\u00eb q\u00eb p\u00ebrjetojn\u00eb pacient\u00ebt, gj\u00eb q\u00eb meriton k\u00ebrkime t\u00eb m\u00ebtejshme tek njer\u00ebzit.<\/p>\n
Gjithashtu sugjeron q\u00eb trajtimi i depresionit ose ankthit q\u00eb ndodh me tinitus k\u00ebrkon kujdes n\u00eb procesin e trajtimit.<\/p>\n
“Studimi yn\u00eb tregon nj\u00eb ekuilib\u00ebr delikat. Mund t\u00eb jet\u00eb e mundur t\u00eb zhvillohen ila\u00e7e specifike p\u00ebr qelizat ose rajonet e trurit q\u00eb synojn\u00eb rritjen e serotonin\u00ebs n\u00eb disa rajone t\u00eb trurit, por jo n\u00eb t\u00eb tjera. N\u00eb k\u00ebt\u00eb m\u00ebnyr\u00eb, mund t\u00eb jet\u00eb e mundur t\u00eb ndahen efektet e dobishme dhe t\u00eb r\u00ebnd\u00ebsishme t\u00eb antidepresiv\u00ebve nga efektet potencialisht t\u00eb d\u00ebmshme n\u00eb d\u00ebgjim”, shton Dr. Trussell.<\/p>\n
Gjetjet u botuan n\u00eb Proceedings of the National Academy of Sciences.<\/p>\n","protected":false},"excerpt":{"rendered":"
Shkenc\u00ebtar\u00ebt tregojn\u00eb se nj\u00eb \u00e7rregullim n\u00eb nivelin e neurotransmetuesve mund t\u00eb luaj\u00eb nj\u00eb rol t\u00eb…<\/p>\n","protected":false},"author":6,"featured_media":8521,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-8518","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bote"],"_links":{"self":[{"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/posts\/8518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8518"}],"version-history":[{"count":1,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/posts\/8518\/revisions"}],"predecessor-version":[{"id":8522,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/posts\/8518\/revisions\/8522"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=\/wp\/v2\/media\/8521"}],"wp:attachment":[{"href":"https:\/\/faktiditor.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=8518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/faktiditor.ch\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=8518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}